I was about to say, “yes, you definitely should” and then I realized it was your thread to start with.
All of them are probably going to be some work to wrap your head around (more or less depending on your background). All of them are going to turn into “coding” at some point. They’re all best at different things so it depends a lot on what you’re looking to do.
I thought there was a spreadsheet somewhere (not really a comparison, but at least listing various features) but I can’t seem to find it.
Twine is pretty beginner-friendly if you want to write stories made up of pages that link to each other: it’s essentially a wiki engine. Beyond that it gets trickier.
Inklewriter is quite beginner-friendly if you like graphical interfaces and want to write things that are text-followed-by-choices and then choices give you more text. It has a tutorial “game” that you play (and edit, IIRC) as you go through. Ink is like Inklewriter but for people who’d rather working in plain text instead of a graphical tool. Still trying to be very straightforward readable “code” that’s easy to edit and write for wordsmithing people.
Texture is a little editor for making stories that use two-part commands where you drag one word onto the other (drag “deliver” onto “pizza” to make “deliver pizza”). IIRC it’s pretty easy to use.
Inform7 is probably the most popular system for making “text-adventure” style games, where you’re exploring a space made up of “rooms” and you can pick up objects and do things with them. It has English-like “code” which looks friendly (but don’t be fooled, it’s still code). You can twist it into doing other things, but that’s its sweet spot. And there are other tools TADS, Dialog, etc. for doing similar things but if you’re not a programmer Inform7 is arguably the easiest to get started with and the fastest to get help with on here?
If you want to make three-color chunky pixel adventures with little bits of dialog, you might check out Bitsy.
ChoiceScript has a similar output format to Ink or Inklewriter: a chunk of text followed by choices. IIRC it has a couple of license restrictions (commercial games allowed only through their site?) but if you want to make looong interactive novels with interesting character stats and usually romance, they have an existing audience who might buy your work.
There are, of course, a million other tools/systems, but IMO those are a good sampling to pick from for your first game…