+1 Anchorhead.
Arguably, Babel.
The King Of Shreds And Patches I haven’t played it, but everyone seems to rate it very highly and I’m antecipating it.
Ecdysis does what it does extremely well.
Fish Bowl is very atmospheric. YMMV, but I found it worth playing and can recommend it.
As far as design goes, “loneliness” seems to be a common theme, which is EXTREMELY easy to do in IF. 
In fact, it’s hard to achieve the opposite!