It does, but it has nothing to do with sexual preference nor orientation.
The word cisgender is the antonym of transgender. Many people shorten these to “cis” and “trans.”
It means a person whose identity does not conflict with the physical gender they were born as and does not experience gender dysphoria. I don’t think it’s presumptive of me to say most people are cis and do not entertain serious thoughts that they need to transition.
It has nothing to do with sexual preference or orientation, nor surface-level questioning of gender. I have known cis drag performers who just like dressing up but are perfectly comfortable living as men, or presenting outwardly as female/fluid/androgynous at their discretion but they do not fundamentally identify as a different gender. My best friend is a trans straight man who for the first half of his life did not recognize himself in the mirror. He is now happily married to a (cis) woman and has never had a sexual experience with a man.
Originally, “cis” and “trans” came into English from Latin, as part of technical nomenclature in chemistry; in Latin, trans- means “across” and cis- means “not across”, as in Cisalpine Gaul (“the Gaul on our side of the Alps”, now belonging to Italy) and Transalpine Gaul (“the Gaul on the other side of the Alps”, now belonging to France). In chemistry, a cis isomer is one with the radicals on the same side of the molecule, and a trans isomer has them on opposite sides.
The Italian descendants are tra- and citeriore; cis didn’t survive on its own, only in the comparative “closer than the other one”.
Right – I mostly know this through ultramontanism (a Catholic principle that the pope should have power beyond the mountains, i.e. outside of Italy). Which I think started to be developed a bit before the Reformation, so that’s one marker for when the slippage was solidified I suppose.