Sure, but to produce a hot take (if perhaps not an unpopular opinion): how many expanded IF works are going to use those? Images and sound are already usable in modern interpreter IF and hardly get a lot of use (aside from cover art in the case of images). I’m not sure any parser game in this year’s IF Comp made much use of audio other than Jim Nelson’s Cognomen, Damon L. Wakes’s game, and The Curse (at least according to the blurb).
I would imagine that the major beneficiary of native executables becoming more common, or IF tools targeting a general runtime becoming more common, or Vorple, WebUI, and the like becoming more common, or some JS-based parser environment becoming more common and so on, would not be the sort of multimedia experience discussed by you but UI tweaks, stylings, and alterations. These would still probably require tuning for different platforms but perhaps not as much.
Just because the browser might not be able to handle, say, Discourse, doesn’t mean that the browser would be unable to handle Twine games.