The discussion in this related thread should be helpful:
Yeah, that’d work.
So far as I’ve heard, terps in screenreaders don’t read the contents of the status line unless the user goes out of their way to request it to do so. But prompting with a “Are you using a screenreader?” question up front and turning off the status line if they are removes any doubt.
But either way, it’s an author’s responsibility to ensure that no significant info appears in the status line that isn’t readily available another way, and that no notifications or status changes the player needs to know occur only in the status line.